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Article

Variants in the GH-IGF axis confer susceptibility to lung cancer.

Genome research - 1 Jun 2006

Rudd Matthew F, Webb Emily L, Matakidou Athena, Sellick Gabrielle S, Williams Richard D, Bridle Helen, Eisen Tim, Houlston Richard S

Abstract excerpt

We conducted a large-scale genome-wide association study in UK Caucasians to identify susceptibility alleles for lung cancer, analyzing 1529 cases and 2707 controls. To increase the likelihood of identifying disease-causing alleles, we genotyped 1476 nonsynonymous single nucleotide polymorphisms (nsSNPs) in 871 candidate cancer genes, biasing SNP selection toward those predicted to be deleterious. Statistically...

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Source

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Identifiers

PMID: 16741161
DOI: 10.1101/gr.5120106
PMCID: PMC1473180

Genes

AKAP9
BRCA2
CAMKK1
GHR
XRCC4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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