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Article

Oncoprotein EWS-FLI1 Activity Is Enhanced by RNA Helicase A

1 Jun 2006

Abstract excerpt

RNA helicase A (RHA), a member of the DEXH box helicase family of proteins, is an integral component of protein complexes that regulate transcription and splicing. The EWS-FLI1 oncoprotein is expressed as a result of the chromosomal translocation t(11;22) that occurs in patients with the Ewing's sarcoma family of tumors (ESFT). Using phage display library screening, we identified an EWS-FLI1 binding peptide...

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PMID: 16740692
DOI: 10.1158/0008-5472.can-05-3293

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