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Article

Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI

1 Jan 1998

Abstract excerpt

We have isolated a novel cDNA encoding a peptide with 86% sequence homology to hSNF2L protein, a previously isolated human homologue of Drosophila ISWI. This gene, designated SMARCA5, contained an open reading frame of 3,156 nucleotides encoding a 1,052 amino-acid peptide (hSNF2H). As this product also revealed a significant (73%) identity in amino acid sequence to ISWI, a key component of chromatin-remodeling...

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PMID: 9730600
DOI: 10.1159/000015027

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