Article
YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues.
Molecular microbiology - 1 Apr 2008
Kozmin Stanislav G, Leroy Prune, Pavlov Youri I, Schaaper Roel M
Abstract excerpt
We have shown previously that lack of molybdenum cofactor (MoCo) in Escherichia coli leads to hypersensitivity to the mutagenic and toxic effects of N-hydroxylated base analogues, such as 6-N-hydroxylaminopurine (HAP). However, the nature of the MoCo-dependent mechanism is unknown, as inactivatio...
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