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Article

YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues.

Molecular microbiology - 1 Apr 2008

Kozmin Stanislav G, Leroy Prune, Pavlov Youri I, Schaaper Roel M

Abstract excerpt

We have shown previously that lack of molybdenum cofactor (MoCo) in Escherichia coli leads to hypersensitivity to the mutagenic and toxic effects of N-hydroxylated base analogues, such as 6-N-hydroxylaminopurine (HAP). However, the nature of the MoCo-dependent mechanism is unknown, as inactivation of all known and putative E. coli molybdoenzymes does not produce any sensitivity. Presently, we report on the...

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Identifiers

PMID: 18312271
DOI: 10.1111/j.1365-2958.2008.06128.x
PMCID: PMC2740630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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