Article
Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 2003
Meunier Dominique, Aubin Josée, Jeannotte Lucie
Abstract excerpt
The Hox family of transcriptional regulators has been extensively studied for their role in axial and appendicular patterning. Genetic analyses have also unveiled Hox gene function in organogenesis and postnatal development. A phenotypical survey of the Hoxa5(-/-) mutant mice shows that the surviving mutants display symptoms of hypothyroidism, including transient growth retardation, and delayed eye opening and...
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