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Article

Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations.

Molecular immunology - 1 Feb 2007

Epeldegui Marta, Hung Yee Ping, McQuay Amy, Ambinder Richard F, Martínez-Maza Otoniel

Abstract excerpt

Infection of human B cells with Epstein-Barr virus (EBV) was seen to result in activation-induced cytidine deaminase (AID) and polymerase-eta (pol-eta) gene expression. AID and pol-eta are cellular gene products that play central roles in the DNA-modifying processes involved in immunoglobulin gene class switch recombination and somatic hypermutation. Errors in these processes can result in oncogene...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Cell Transformation, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to DNA-Directed DNA Polymerase

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Share to Lymphoma, B-Cell

Share to Proto-Oncogene Proteins c-bcl-6

Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 16730063
DOI: 10.1016/j.molimm.2006.03.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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