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Article

SOCS1 Is a Suppressor of Liver Fibrosis and Hepatitis-induced Carcinogenesis

14 Jun 2004

Abstract excerpt

Hepatocellular carcinomas (HCCs) mainly develop from liver cirrhosis and severe liver fibrosis that are established with long-lasting inflammation of the liver. Silencing of the suppressor of the cytokine signaling-1 (SOCS1) gene, a negative regulator of cytokine signaling, by DNA methylation has been implicated in development or progress of HCC. However, how SOCS1 contributes to HCC is unknown. We examined SOCS1...

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PMID: 15197228
DOI: 10.1084/jem.20031675

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