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Article

Variations in the peroxisome proliferator-activated receptor-gamma gene and melanoma risk.

Cancer letters - 8 Feb 2007

Mössner Rotraut, Meyer Peter, Jankowski Florian, König Inke R, Krüger Ullrich, Kammerer Stefan, Westphal Götz, Boettger Melanie B, Berking Carola, Schmitt Christina, Brockmöller Jürgen, Ziegler Andreas, Stapelmann Henrike, Kaiser Rolf, Volkenandt Matthias, Reich Kristian

Abstract excerpt

There is strong evidence to suggest that the peroxisome proliferator-activated receptor (PPAR)-gamma, a member of the nuclear receptor family of transcriptional regulators, mediates tumor suppressive activities in a variety of human cancers. Recently, PPARgamma agonists were found to inhibit growth of melanoma cell lines. Here, we tested the possibility that variations in the gene encoding PPARgamma (PPARG)...

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Source

Identifiers

PMID: 16713673
DOI: 10.1016/j.canlet.2006.02.022

Genes

PPARG

Variants

rs1801282
rs1801282

Provenance

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