Article
A polymorphism in the promoter region of the CD86 (B7.2) gene is associated with systemic sclerosis.
International journal of immunogenetics - 1 Jun 2006
Abdallah A M, Renzoni E A, Anevlavis S, Lagan A L, Munkonge F M, Fonseca C, Black C M, Briggs D, Wells A U, Marshall S E, McHugh N, du Bois R M, Welsh K I
Abstract excerpt
Systemic sclerosis (SSc) is a connective tissue disease of unknown aetiology characterized by fibrosis of the skin and internal organs, vascular abnormalities and humoral autoimmunity. Strong T-cell-dependent autoantibody and HLA associations are found in SSc subsets. The co-stimulatory molecule, CD86, expressed by antigen-presenting cells, plays a crucial role in priming naïve lymphocytes. We hypothesized that...
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