Article
Genetic variation at the plasminogen activator inhibitor-1 locus is associated with altered levels of plasma plasminogen activator inhibitor-1 activity.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Jan 2000
Dawson S, Hamsten A, Wiman B, Henney A, Humphries S
Abstract excerpt
Plasminogen activator inhibitor-1 (PAI-1), a rapid inhibitor of tissue-type plasminogen activator, has been shown to be an independent risk factor for recurrent myocardial infarction (MI) at a young age. To investigate whether genetic variation in the PAI-1 gene is affecting plasma PAI-1 levels,...
Topics
- Adult
- Base Sequence
- Female
- Follow-Up Studies
- Genetic Variation
- Humans
- Lipoproteins, VLDL
- Male
- Molecular Sequence Data
- Myocardial Infarction
- Pedigree
- Plasminogen Inactivators
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Risk Factors
- Triglycerides