Article
B-cell acute lymphoblastic leukemia with mature phenotype and MLL rearrangement: report of five new cases and review of the literature.
Leukemia & lymphoma - 1 Oct 2016
Sajaroff Elisa Olga, Mansini Adrian, Rubio Patricia, Alonso Cristina Noemí, Gallego Marta S, Coccé Mariela C, Eandi-Eberle Silvia, Bernasconi Andrea Raquel, Ampatzidou Maria, Paterakis George, Papadhimitriou Stefanos I, Petrikkos Loizos, Papadakis Vassilios, Polychronopoulou Sophia, Rossi Jorge G, Felice Maria Sara
Abstract excerpt
The association between mature-B phenotype and MLL abnormalities in acute lymphoblastic leukemia (ALL) is a very unusual finding; only 14 pediatric cases have been reported so far. We describe the clinical and biological characteristics and outcome of five pediatric cases of newly diagnosed B lineage ALL with MLL abnormalities and mature immunophenotype based on light chain restriction and surface Ig expression....
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