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Article

RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2006

Tsutsumida Hideaki, Swanson Benjamin J, Singh Pankaj K, Caffrey Thomas C, Kitajima Shinichi, Goto Masamichi, Yonezawa Suguru, Hollingsworth Michael A

Abstract excerpt

MUC1 is a highly glycosylated, type I transmembrane protein expressed by normal ductal epithelial cells of the pancreas, breast, lung, and gastrointestinal tract, and overexpressed in many cases of adenocarcinoma. We down-regulated MUC1 expression by RNA interference and investigated the effects on malignant and metastatic potential of a human pancreatic cancer cell line, S2-013. MUC1-suppressed clones,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16707592
DOI: 10.1158/1078-0432.CCR-05-1197

Genes

MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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