Article
H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.
Oncotarget - 6 Oct 2015
Vennin Constance, Spruyt Nathalie, Dahmani Fatima, Julien Sylvain, Bertucci François, Finetti Pascal, Chassat Thierry, Bourette Roland P, Le Bourhis Xuefen, Adriaenssens Eric
Abstract excerpt
H19 is a long non-coding RNA precursor of miR-675 microRNA. H19 is increasingly described to play key roles in the progression and metastasis of cancers from different tissue origins. We have previously shown that the H19 gene is activated by growth factors and increases breast cancer cell invasion. In this study, we established H19/miR-675 ectopic expression models of MDA-MB-231 breast cancer cells to further...
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