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Article

Amino acid substitutions affecting protein dynamics in eglin C do not affect heat capacity change upon unfolding.

Proteins - 1 Aug 2006

Gribenko Alexey V, Keiffer Timothy R, Makhatadze George I

Abstract excerpt

The heat capacity change upon unfolding (deltaC(p)) is a thermodynamic parameter that defines the temperature dependence of the thermodynamic stability of proteins; however, physical basis of the heat capacity change is not completely understood. Although empirical surface area-based calculations can predict heat capacity changes reasonably well, accumulating evidence suggests that changes in hydration of those...

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PMID: 16705642
DOI: 10.1002/prot.20974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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