Testing hypotheses about determinants of protein structure with high-precision, high-throughput stability measurements and statistical modeling.

Abstract excerpt

Statistical modeling provides the mathematics to use data from large numbers of mutant proteins to generate information about hypotheses concerning protein structure not easily obtained from anecdotal studies on small numbers of mutants. Here we use the unfolding free energies of 303 unique eglin c mutant proteins obtained from high-precision, high-throughput chemical denaturation measurements to assess models...

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