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Article

Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas.

PloS one - 1 Jan 2017

Lu Liming, Zeng Jingchun

Abstract excerpt

Genetic alterations in K-ras and p53 are thought to be critical in pancreatic cancer development and progression. However, K-ras and p53 expression in pancreatic adenocarcinoma have not been systematically examined in The Cancer Genome Atlas (TCGA) Data Portal. Information regarding K-ras and p53 alterations, mRNA expression data, and protein/protein phosphorylation abundance was retrieved from The Cancer Genome...

Topics

Adenocarcinoma
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Genes, p53
Genes, ras
Humans
Kaplan-Meier Estimate
Mutation
Pancreas
Pancreatic Neoplasms
Proto-Oncogene Proteins p21(ras)

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Tumor Suppressor Protein p53

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Identifiers

PMID: 28742845
DOI: 10.1371/journal.pone.0181532
PMCID: PMC5526503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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