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Article

Genetic and functional analysis of pyroglutamyl-peptidase I in coeliac disease.

European journal of gastroenterology & hepatology - 1 Jun 2006

Monsuur Alienke J, Stepniak Dariusz, Diosdado Begoña, Wapenaar Martin C, Mearin Maria Luisa, Koning Frits, Wijmenga Cisca

Abstract excerpt

Coeliac disease (CD) is an enteropathy caused by an immune reaction towards wheat gluten and similar proteins from barley and rye. It was shown that some gluten peptides spontaneously form N-terminal L-pyroglutamate. This modification could potentially make gluten more resistant to proteolytic degradation within the intestine. Pyroglutamyl-peptidase I (PGPEPI) is an enzyme that hydrolytically removes the...

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PMID: 16702853
DOI: 10.1097/00042737-200606000-00010

Genes

PGPEP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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