Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23.

doi:10.1093/brain/awl120

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23.

Brain : a journal of neurology - 1 Sept 2006

Shatunov Alexey, Sambuughin Nyamkhishig, Jankovic Joseph, Elble Rodger, Lee Hee Suk, Singleton Andrew B, Dagvadorj Ayush, Ji Jay, Zhang Yiping, Kimonis Virginia E, Hardy John, Hallett Mark, Goldfarb Lev G

Abstract excerpt

Essential tremor (ET) is the most prevalent adult-onset movement disorder showing evidence of non-random accumulation in some families. ET has previously been mapped to genetic loci on chromosomes 2p and 3q, but no causative genes identified. We conducted genomewide linkage screening with subsequent fine mapping in seven large North American families comprising a total of 325 genotyped individuals that included...

Topics

Adult
Age of Onset
Chromosome Mapping
Chromosomes, Human, Pair 6
DNA Mutational Analysis
Dystonia
Family Health
Female
Genetic Linkage
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genotype

Haplotypes

Humans

Male

Microsatellite Repeats

Middle Aged

Pedigree

Source

Open in PubMed

Identifiers

PMID: 16702189
DOI: 10.1093/brain/awl120

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23.PMID 16702189Read ↗

Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology.Semantic proximity Read ↗

Evidence that a gene for essential tremor maps to chromosome 2p in four families.Semantic proximity Read ↗

Genome-wide linkage scan maps ETINPH gene to chromosome 19q12-13.31.Semantic proximity Read ↗

Mapping of a familial essential tremor gene, FET1, to chromosome 3q13.Semantic proximity Read ↗

Genetics of essential tremor.Semantic proximity Read ↗

Update on genetics of essential tremor.Semantic proximity Read ↗

Genetics of essential tremor.Semantic proximity Read ↗

Association of Essential Tremor With Novel Risk Loci: A Genome-Wide Association Study and Meta-analysis.Semantic proximity Read ↗

Genome-wide association study in essential tremor identifies three new loci.Semantic proximity Read ↗

Genome-Wide Meta-Analysis Identifies 47 Novel Loci and Links Essential Tremor to Ventral Diencephalon and Cerebellum MorphometrySemantic proximity Read ↗

Essential tremor.Semantic proximity Read ↗

Genetic mapping in human disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.