Article
Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23.
Brain : a journal of neurology - 1 Sept 2006
Shatunov Alexey, Sambuughin Nyamkhishig, Jankovic Joseph, Elble Rodger, Lee Hee Suk, Singleton Andrew B, Dagvadorj Ayush, Ji Jay, Zhang Yiping, Kimonis Virginia E, Hardy John, Hallett Mark, Goldfarb Lev G
Abstract excerpt
Essential tremor (ET) is the most prevalent adult-onset movement disorder showing evidence of non-random accumulation in some families. ET has previously been mapped to genetic loci on chromosomes 2p and 3q, but no causative genes identified. We conducted genomewide linkage screening with subsequent fine mapping in seven large North American families comprising a total of 325 genotyped individuals that included...
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