Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology.

doi:10.1016/j.ebiom.2022.104290

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Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology.

EBioMedicine - 1 Nov 2022

Clark Lorraine N, Gao Yizhe, Wang Gao T, Hernandez Nora, Ashley-Koch Allison, Jankovic Joseph, Ottman Ruth, Leal Suzanne M, Rodriguez Sandra M Barral, Louis Elan D

Abstract excerpt

BACKGROUND: Essential tremor (ET), one of the most common neurological disorders, has a phenotypically heterogeneous presentation characterized by bilateral kinetic tremor of the arms and, in some patients, tremor involving other body regions (e.g., head, voice). Genetic studies suggest that ET is genetically heterogeneous. METHODS: We analyzed whole genome sequence data (WGS) generated on 104 multi-generational...

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Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology.

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