Article
Genome-wide association study in essential tremor identifies three new loci.
Brain : a journal of neurology - 1 Dec 2016
Müller Stefanie H, Girard Simon L, Hopfner Franziska, Merner Nancy D, Bourassa Cynthia V, Lorenz Delia, Clark Lorraine N, Tittmann Lukas, Soto-Ortolaza Alexandra I, Klebe Stephan, Hallett Mark, Schneider Susanne A, Hodgkinson Colin A, Lieb Wolfgang, Wszolek Zbigniew K, Pendziwiat Manuela, Lorenzo-Betancor Oswaldo, Poewe Werner, Ortega-Cubero Sara, Seppi Klaus, Rajput Alex, Hussl Anna, Rajput Ali H, Berg Daniela, Dion Patrick A, Wurster Isabel, Shulman Joshua M, Srulijes Karin, Haubenberger Dietrich, Pastor Pau, Vilariño-Güell Carles, Postuma Ronald B, Bernard Geneviève, Ladwig Karl-Heinz, Dupré Nicolas, Jankovic Joseph, Strauch Konstantin, Panisset Michel, Winkelmann Juliane, Testa Claudia M, Reischl Eva, Zeuner Kirsten E, Ross Owen A, Arzberger Thomas, Chouinard Sylvain, Deuschl Günther, Louis Elan D, Kuhlenbäumer Gregor, Rouleau Guy A
Abstract excerpt
We conducted a genome-wide association study of essential tremor, a common movement disorder characterized mainly by a postural and kinetic tremor of the upper extremities. Twin and family history studies show a high heritability for essential tremor. The molecular genetic determinants of essential tremor are unknown. We included 2807 patients and 6441 controls of European descent in our two-stage genome-wide...
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