-251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case-control studies.

doi:10.1007/s11033-011-1042-5

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Article

-251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case-control studies.

Molecular biology reports - 1 Mar 2012

Wang Na, Zhou Rongmiao, Wang Chunmei, Guo Xiaoqing, Chen Zhifeng, Yang Shan, Li Yan

Abstract excerpt

The -251T/A (rs4073), a single nucleotide polymorphism, has been identified in the promoter region of the interleukin-8 (IL-8) gene. It's presence could influence the production of IL-8 protein by regulating the transcriptional activity of the gene. A large number of studies have been performed to evaluate the role of -251T/A polymorphism on various cancers, with inconsistent results being reported. In this...

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PMID: 21681427
DOI: 10.1007/s11033-011-1042-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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