Article
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans.
Cancer cell - 1 May 2006
Carrasco Daniel R, Fenton Tim, Sukhdeo Kumar, Protopopova Marina, Enos Miriam, You Mingjian J, Di Vizio Dolores, Divicio Dolores, Nogueira Cristina, Stommel Jayne, Pinkus Geraldine S, Fletcher Christopher, Hornick Jason L, Cavenee Webster K, Furnari Frank B, Depinho Ronald A
Abstract excerpt
Histiocytic sarcoma (HS) is a rare malignant proliferation of histiocytes of uncertain molecular pathogenesis. Here, genetic analysis of coincident loss of Pten and Ink4a/Arf tumor suppressors in the mouse revealed a neoplastic phenotype dominated by a premalignant expansion of biphenotypic myelolymphoid cells followed by the development of HS. Pten protein loss occurred only in the histiocytic portion of tumors,...
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