Article
Differential role played by the MEK/ERK/EGR-1 pathway in orthopoxviruses vaccinia and cowpox biology.
The Biochemical journal - 15 Aug 2006
Silva Patrícia N G, Soares Jamária A P, Brasil Bruno S A F, Nogueira Sarah V, Andrade Anderson A, de Magalhães José C, Bonjardim Marisa B, Ferreira Paulo C P, Kroon Erna G, Bruna-Romero Oscar, Bonjardim Cláudio A
Abstract excerpt
Appropriation of signalling pathways facilitates poxvirus replication. Poxviruses, as do most viruses, try to modify the host cell environment to achieve favourable replication conditions. In the present study, we show that the early growth response 1 gene (egr-1) is one of the host cell factors intensely modulated by the orthopoxviruses VV (vaccinia virus) and CPV (cowpox virus). These viruses stimulated the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.