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Article

Impact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies.

Cell death & disease - 1 May 2024

Giolito Maria Virginia, Bodoirat Serguei, La Rosa Theo, Reslinger Mathieu, Guardia Gabriela D A, Mourtada Jana, Claret Leo, Joung Alain, Galante Pedro A F, Penalva Luiz O F, Plateroti Michelina

Abstract excerpt

Colorectal cancers (CRCs) are highly heterogeneous and show a hierarchical organization, with cancer stem cells (CSCs) responsible for tumor development, maintenance, and drug resistance. Our previous studies showed the importance of thyroid hormone-dependent signaling on intestinal tumor development and progression through action on stem cells. These results have a translational value, given that the thyroid...

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PMID: 38693105
DOI: 10.1038/s41419-024-06690-x
PMCID: PMC11063186

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ABCB1
ABCG2
ALDH1A1

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