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Article

Ordered genotypes: an extended ITO method and a general formula for genetic covariance.

American journal of human genetics - 1 Jun 2006

Dai Feng, Weeks Daniel E

Abstract excerpt

Traditionally, the stochastic ITO transition matrices provide a simple general method for obtaining the joint genotype distribution and genotypic correlations between any specified pair of noninbred relatives. The ITO method has been widely used in modern genetic analysis; however, since it was originally derived for unordered genotypes, it is not very useful in some new applications -- for example, when one is...

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PMID: 16685653
DOI: 10.1086/504045
PMCID: PMC1474083

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