Angiogenesis during human extraembryonic development involves the spatiotemporal control of PDGF ligand and receptor gene expression

doi:10.1242/dev.113.3.749

Article

Angiogenesis during human extraembryonic development involves the spatiotemporal control of PDGF ligand and receptor gene expression

1 Nov 1991

Abstract excerpt

We have examined the role of platelet-derived growth factor (PDGF) ligand and receptor genes in the angiogenic process of the developing human placenta. In situ hybridization analysis of first trimester placentae showed that most microcapillary endothelial cells coexpress the PDGF-B and PDGF beta-receptor genes. This observation indicates that PDGF-B may participate in placental angiogenesis by forming...

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