Article
Ethnic differences in response to epidermal growth factor receptor tyrosine kinase inhibitors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2006
Calvo Emiliano, Baselga José
Abstract excerpt
The identification of somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and their correlation with response to EGFR inhibitors has become an important event in the fields of cancer genetics and therapeutics. The initial observation of a higher response to gefitinib and erlotinib in patients of Asian origin was followed by the...
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