Article
Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody.
Protein engineering, design & selection : PEDS - 1 Jul 2006
Reid Carl, Rushe Mia, Jarpe Matthew, van Vlijmen Herman, Dolinski Brian, Qian Fang, Cachero Teresa G, Cuervo Hernan, Yanachkova Milka, Nwankwo Chioma, Wang Xin, Etienne Natalie, Garber Ellen, Bailly Véronique, de Fougerolles Antonin, Boriack-Sjodin P Ann
Abstract excerpt
Monocyte chemoattractant proteins (MCPs) are cytokines that direct immune cells bearing appropriate receptors to sites of inflammation or injury and are therefore attractive therapeutic targets for inhibitory molecules. 11K2 is a blocking mouse monoclonal antibody active against several human and murine MCPs. A 2.5 A structure of the Fab fragment of this antibody in complex with human MCP-1 has been solved. The...
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