Article
Transcriptional response of Candida albicans upon internalization by macrophages.
Eukaryotic cell - 1 Oct 2004
Lorenz Michael C, Bender Jennifer A, Fink Gerald R
Abstract excerpt
The opportunistic fungal pathogen Candida albicans is both a benign gut commensal and a frequently fatal systemic pathogen. The interaction of C. albicans with the host's innate immune system is the primary factor in this balance; defects in innate immunity predispose the patient to disseminated candidiasis. Because of the central importance of phagocytic cells in defense against fungal infections, we have...
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