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Article

BDNF val66met polymorphism influences motor system function in the human brain.

Cerebral cortex (New York, N.Y. : 1991) - 1 May 2010

McHughen Stephanie A, Rodriguez Paul F, Kleim Jeffrey A, Kleim Erin D, Marchal Crespo Laura, Procaccio Vincent, Cramer Steven C

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is important to brain functions such as plasticity and repair. A single nucleotide polymorphism for this growth factor, val(66)met, is common and associated with decreased activity-dependent BDNF release. The current study evaluated the effects of this polymorphism in relation to human brain motor system function, short-term plasticity, and learning. Functional magnetic...

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Source

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Identifiers

PMID: 19745020
DOI: 10.1093/cercor/bhp189
PMCID: PMC2852510

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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