Article
Intense training overcomes effects of the Val66Met BDNF polymorphism on short-term plasticity.
Experimental brain research - 1 Sept 2011
McHughen Stephanie A, Pearson-Fuhrhop Kristin, Ngo Vivian K, Cramer Steven C
Abstract excerpt
The val(66)met polymorphism in the brain-derived neurotrophic factor (BDNF) gene impacts activity-dependent secretion of BDNF and modifies short-term cortical plasticity. The current study examined whether sustained training overcomes polymorphism effects on short-term plasticity and also examined polymorphism effects on long-term plasticity. Twenty-four subjects completed a 12-day protocol of daily training on a...
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