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Article

Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.

The Journal of pharmacology and experimental therapeutics - 1 Aug 2006

Ansonoff Michael A, Zhang Jiwen, Czyzyk Traci, Rothman Richard B, Stewart Jeremy, Xu Heng, Zjwiony Jordan, Siebert Daniel J, Yang Feng, Roth Bryan L, Pintar John E

Abstract excerpt

Salvia divinorum is a natural occurring hallucinogen that is traditionally used by the Mazatec Indians of central Mexico. The diterpene salvinorin A was identified as an active component of S. divinorum over 20 years ago, but only recently has biochemical screening indicated that a molecular target of salvinorin A in vitro is the kappa-opioid receptor. We have examined whether salvinorin A, the C2-substituted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16672569
DOI: 10.1124/jpet.106.101998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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