Article
Cell cycle regulation score predicts relapse-free survival in non-germinal centre diffuse large B-cell lymphoma patients treated by means of immunochemotherapy.
European journal of haematology - 1 Jul 2013
Pasanen Anna Kaisa, Haapasaari Kirsi-Maria, Peltonen Jenni, Soini Ylermi, Jantunen Esa, Bloigu Risto, Turpeenniemi-Hujanen Taina, Kuittinen Outi
Abstract excerpt
OBJECTIVES: The cell cycle is under strict regulation by the retinoblastoma, p53 and p27 pathways, and the disruption of these pathways is an important characteristic of diffuse large B-cell lymphoma (DLBCL). In this study, we wanted to assess the function and prognostic significance of these pathways in DLBCL patients. METHODS: Tissue samples from 120 DLBCL patients treated by means of R-CHOP-type chemotherapy...
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