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Article

SOX2 is a dose-dependent regulator of retinal neural progenitor competence.

Genes & development - 1 May 2006

Taranova Olena V, Magness Scott T, Fagan B Matthew, Wu Yongqin, Surzenko Natalie, Hutton Scott R, Pevny Larysa H

Abstract excerpt

Approximately 10% of humans with anophthalmia (absent eye) or severe microphthalmia (small eye) show haploid insufficiency due to mutations in SOX2, a SOXB1-HMG box transcription factor. However, at present, the molecular or cellular mechanisms responsible for these conditions are poorly understood. Here, we directly assessed the requirement for SOX2 during eye development by generating a gene-dosage allelic...

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Source

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Identifiers

PMID: 16651659
DOI: 10.1101/gad.1407906
PMCID: PMC1472477

Genes

SOX2
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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