Article
Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2004
Wakamatsu Yoshio, Endo Yukinori, Osumi Noriko, Weston James A
Abstract excerpt
Expression of Sox2, which encodes an HMG-box-type transcription factor, is down-regulated in the neural plate when neural crest segregates from dorsal neural tube and remains low during crest cell migration. Sox2 expression is subsequently up-regulated in some crest-derived cells in the developing peripheral nervous system and is later restricted to glial sublineages. Misexpression of Sox2 and mutant forms of...
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