Article
Molecular genetics of familial hypertrophic cardiomyopathy (FHC).
Journal of human genetics - 1 Jan 2003
Bashyam Murali D, Savithri Gorinabele R, Kumar Murugapiran S, Narasimhan Calambur, Nallari Pratibha
Abstract excerpt
Familial hypertrophic cardiomyopathy is an autosomal dominant disease with a wide range of clinical features from benign to severe, and is the most common cause of sudden death in otherwise healthy individuals. The two prominent clinical features are left ventricular hypertrophy and myocyte/myofibrillar disarray. The former is responsible for clinical symptoms such as breathlessness and angina, whereas the latter...
Topics
- Cardiac Myosins
- Cardiomyopathy, Hypertrophic, Familial
- Carrier Proteins
- Connectin
- Genetic Heterogeneity
- Humans
- Muscle Proteins
- Mutation
- Myosin Heavy Chains
- Myosin Light Chains
- Protein Kinases
- Sarcomeres
- Tropomyosin
- Troponin T