Article
Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes.
Cancer - 1 Mar 2010
Rimawi Mothaffar F, Shetty Priya B, Weiss Heidi L, Schiff Rachel, Osborne C Kent, Chamness Gary C, Elledge Richard M
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) expression is associated with aggressive phenotypes in preclinical breast cancer models, but in clinical studies, EGFR has been inconsistently linked to poor outcome. We hypothesized that EGFR expression in human breast tumors, when centrally and uniformly assessed, is associated with an aggressive phenotype and resistance to systemic therapy. METHODS: In a...
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