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Determination of sequential mutation accumulation in pancreas and bile duct brushing cytology.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2006

Lapkus Odeta, Gologan Olguta, Liu Yulin, Swalsky Patricia A, Wilson Matthew M, Finkelstein Sydney D, Silverman Jan F

Abstract excerpt

Neoplastic progression is characterized by clonal expansion of tumor cells associated with accumulation of mutational damage. The timing of mutation acquisition could be of value in distinguishing preneoplastic conditions from early and advanced cancer as well as characterizing tumor aggressiveness and treatment response. Using quantitative methods applied to microdissected cell clusters selected according to...

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PMID: 16648872
DOI: 10.1038/modpathol.3800545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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