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Article

Cytomorphologic characteristics of next-generation sequencing-positive bile duct brushing specimens.

Journal of the American Society of Cytopathology - 1 Jan 2000

Rosenbaum Matthew W, Arpin Ronald, Limbocker Jessica, Casey Brenna, Le Long, Dudley Jonathan, Iafrate A John, Pitman Martha B

Abstract excerpt

INTRODUCTION: Cytology of bile duct brushings (BDBs) is a specific, but insensitive, test for malignancy. Next-generation sequencing (NGS) of BDBs has recently been shown to improve sensitivity. We analyzed the cytologic features of NGS-positive (NGS+) and NGS-negative (NGS-) BDBs and correlated the morphology with the presence of mutations. MATERIALS AND METHODS: A total of 96 BDBs were analyzed for 29 cytologic...

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PMID: 32839152
DOI: 10.1016/j.jasc.2020.06.009

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