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Article

SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain

8 Aug 2008

Abstract excerpt

Spinal muscular atrophy (SMA) is a recessive neuromuscular disease caused by mutations in the human survival motor neuron 1 (SMN1) gene. The human SMN protein is part of a large macromolecular complex involved in the biogenesis of small ribonucleoproteins. Previously, we showed that SMN is a sarcomeric protein in flies and mice. In this report, we show that the entire mouse Smn complex localizes to the sarcomeric...

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Identifiers

PMID: 18689355
DOI: 10.1093/hmg/ddn234

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SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpainPMID 18689355Read ↗

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