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Article

The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Apr 2013

Dimitriadi Maria, Kye Min Jeong, Kalloo Geetika, Yersak Jill M, Sahin Mustafa, Hart Anne C

Abstract excerpt

Spinal muscular atrophy (SMA), a recessive neuromuscular disorder, is caused by diminished function of the Survival Motor Neuron (SMN) protein. To define the cellular processes pertinent to SMA, parallel genetic screens were undertaken in Drosophila and Caenorhabditis elegans SMA models to identi...

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Source

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Identifiers

PMID: 23575853
DOI: 10.1523/JNEUROSCI.1536-12.2013
PMCID: PMC3652322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23575853-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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