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Article

Quantification of homozygosity in consanguineous individuals with autosomal recessive disease.

American journal of human genetics - 1 May 2006

Woods C Geoffrey, Cox James, Springell Kelly, Hampshire Daniel J, Mohamed Moin D, McKibbin Martin, Stern Rowena, Raymond F Lucy, Sandford Richard, Malik Sharif Saghira, Karbani Gulshan, Ahmed Mustaq, Bond Jacquelyn, Clayton David, Inglehearn Chris F

Abstract excerpt

Individuals born of consanguineous union have segments of their genomes that are homozygous as a result of inheriting identical ancestral genomic segments through both parents. One consequence of this is an increased incidence of recessive disease within these sibships. Theoretical calculations predict that 6% (1/16) of the genome of a child of first cousins will be homozygous and that the average homozygous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16642444
DOI: 10.1086/503875
PMCID: PMC1474039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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