Article
Association of polymorphisms in the Angiotensin-converting enzyme gene with Alzheimer disease in an Israeli Arab community.
American journal of human genetics - 1 May 2006
Meng Yan, Baldwin Clinton T, Bowirrat Abdalla, Waraska Kristin, Inzelberg Rivka, Friedland Robert P, Farrer Lindsay A
Abstract excerpt
Several lines of evidence support for a role of angiotensin converting enzyme (ACE) in Alzheimer disease (AD). Most genetic studies have focused on an Alu insertion/deletion (I/D) polymorphism in the ACE gene (DCP1) and have yielded conflicting results. We evaluated the association between 15 single-nucleotide polymorphisms (SNPs) in DCP1, including the I/D variant, and AD in a sample of 92 patients with AD and...
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