Article
Rapid screening of glomerular slit diaphragm integrity in larval zebrafish
16 Aug 2007
Abstract excerpt
Gene array-type experiments have identified large numbers of genes thought to be important for the integrity of the glomerular slit diaphragm. Confirmation of individual proteins has been limited by the expenses and time involved in generating transgenic or knockout mice for each candidate. We present a functional screening assay based on the clearance of a 70-kDa fluorescent dextran in another vertebrate system...
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