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Article

Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS‐associated coronavirus

30 Mar 2006

Abstract excerpt

SARS-associated coronavirus was identified as the etiological agent of severe acute respiratory syndrome and a large virus pool was identified in wild animals. Virus generates drug resistance through fast mutagenesis and escapes antiviral treatment. siRNAs targeting different genes would be an alternative for overcoming drug resistance. Here, we report effective siRNAs targeting structural genes (i.e., spike,...

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Share to Advanced biosensing and bioanalysis techniques
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Identifiers

PMID: 16638566
DOI: 10.1016/j.febslet.2006.03.066

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