A novel dual-chimeric surrogate virus to select, test and characterize mutants of protease and glycoprotein inhibitors.

Abstract excerpt

Antivirals are life-saving medications. However, pathogens develop resistances, mitigating their effect. Resistance studies (gain-of-function, GOF) are therefore paramount before and while antivirals are used clinically to characterize resistances and ideally study how to counteract them with other antivirals. The ability to switch from one antiviral, against which the virus is resistant, to another, depends on th...

Topics

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• Computational Drug Discovery Methods
• Coronavirus 3C Proteases
• COVID-19
• COVID-19 Drug Treatment
• Mutation
• SARS-CoV-2
• SARS-CoV-2 and COVID-19 Research
• Spike Glycoprotein, Coronavirus

Identifiers and source

Literature Corpus work

4761b6ec-190b-5d60-8f06-f816e7bed6d1

DOI

10.64898/2026.01.07.698196