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Article

Prophylactic and Therapeutic Effects of Small Interfering Rna Targeting Sars-Coronavirus

1 Apr 2004

Abstract excerpt

OBJECTIVES: To identify and characterize the siRNA duplexes that are effective for inhibition of SARS-CoV infection and replication in the non-human primate cells. This in vitro study will serve as the foundation for development of novel anti-SARS therapeutics. METHODS: 48 siRNA sequences were designed for targeting regions throughout entire SARS-CoV genome RNA including open-reading frames for several key...

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PMID: 15259899
DOI: 10.1177/135965350400900310

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