Article
Isolation of equine herpesvirus-1 mutants in the presence of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine: demonstration of resistance in vitro and in vivo.
Antiviral research - 1 Jul 1991
Field H J, Awan A R, de la Fuente R
Abstract excerpt
The compound (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) had been previously shown to be highly effective in treatment of EHV-1 in a murine model for the equine disease. This paper describes the isolation of a series of mutants resistant to the drug. Resistance was demonstrated in cell culture and one mutant was tested in a murine model. The resistant mutant was pathogenic for mice; infectious...
Topics
- Adenine
- Animals
- Antiviral Agents
- Cell Line
- Drug Resistance, Microbial
- Female
- Herpesviridae Infections
- Herpesvirus 1, Equid
- Mice
- Mice, Inbred BALB C
- Mutation