Effect of Oral Treatment with Hexadecyloxypropyl-[( <i>S</i> )-9-(3-Hydroxy-2- Phosphonylmethoxypropyl)Adenine] [( <i>S</i> )-HPMPA] or Octadecyloxyethyl-( <i>S</i> )-HPMPA on Cowpox or Vaccinia Virus Infections in Mice

Abstract excerpt

We have previously reported that (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, or (S)-HPMPA, is active in vitro against cowpox virus (CV) and vaccinia virus (VV) but is not active orally in animals. However, the ether lipid esters of (S)-HPMPA, hexadecyloxypropyl-[(S)-HPMPA] [HDP-(S)-HPMPA] and octadecyloxyethyl-[(S)-HPMPA] [ODE-(S)-HPMPA], had significantly enhanced activity in vitro and are orally...

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