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Article

Lentiviral vectors harboring a dual-gene system allow high and homogeneous transgene expression in selected polyclonal human embryonic stem cells.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2006

Ben-Dor Israel, Itsykson Pavel, Goldenberg Daniel, Galun Eithan, Reubinoff Benjamin E

Abstract excerpt

Genetic modification of human embryonic stem cells (hESCs) is highly valuable for their exploitation in basic science and therapeutic applications. Here we developed lentiviral vectors (LVs) constitutively expressing a reporter and a selectable marker to enable high and homogeneous transgene expression within polyclonal hESCs. LVs carrying GFP and a downstream puromycin resistance gene, linked by the...

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Identifiers

PMID: 16632408
DOI: 10.1016/j.ymthe.2006.02.010

Genes

PGK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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